Immunogenetics and Cellular Immunology


Overview

CUMC Immunogenetics and Cellular Immunology (ICI) has been a pioneer in the HLA field, with a 50 year history of excellence in clinical testing. We are certified and accredited by the American Society for Histocompatibility and Immunogenetics (ASHI), College of American Pathologists (CAP), The Centers for Medicare & Medicaid Services (CMS) and New York State Department of Health. The ICI laboratories offer comprehensive quality testing and consultation in three distinct NYS DOH areas of accreditation: Histocompatibility, Cellular Immunology and Transplant Monitoring.

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The Immunogenetics and Histocompatibility Laboratory provides a full range of pre- and post-transplant immunological tests for recipients and donors of solid organs or hematopoietic stem cells, such as:

  • HLA genotyping by low and high resolution molecular techniques for transplantation and/or disease association studies.
  • Screening for anti-HLA or donor specific antibodies using complement-mediated cytotoxicity (CDC), Flow Cytometry (FC) and solid phase assays (SPA).
  • Crossmatching of recipients with potential donors by CDC and FC.
  • Post-transplant immune monitoring by CDC, SPA, and lymphocyte growth assay.

Port Transplant Engraftment Monitoring examines donor/recipient chimerism following stem cell transplantation using capillary electrophoretic PCR techniques, including:

  • Whole blood or bone marrow donor engraftment.
  • Lineage specific engraftment (CD3+ T, CD19+ B, CD16&56+ NK, CD15+ myeloid, CD34+ stem cell and CD71+ erythroid precursors can be monitored independently).

Cellular Immunology services include phenotypic and functional examination of hematopoietic cells obtained from peripheral blood, tissue aspirates, lymphoid or non-lymphoid tissues: 

  • Leukemia/Lymphoma diagnostic services.
  • Lymphoid immunophenotyping.
  • CD34 stem cell enumeration
  • Flow cytometry donor/recipient crossmatching
  • Leukocyte function

ICI is an integral part of the teaching and training of residents and fellows in the Department of Pathology and Cell Biology. It also hosts several active research interests relating to transplantation outcomes, generation of immunological tolerance and new biomarker discovery and characterization.

Contact Us

  • New York-Presbyterian Hospital
    Columbia University Medical Center

    Immunogenetics and Cellular Immunology
    Columbia University College of Physicians and Surgeons
  • 630 West 168th Street
    VC Building, Room 15-204
    New York, NY 10032
  • Phone Number: (212) 305-6941
    Fax Number: (212) 305-3429

Lab Hours

  • Monday through Friday from 9:00am–5:00pm
 
Contact the Pathology Webmaster at PathWebMaster@columbia.edu