Graduate Faculty Research Interests

Research Interests
Cory Abate–Shen Understanding the relationship between the processes that control normal development and those that lead to cancer
Swamali Acharyya Exploring mechanisms of drug resistance and cancer metastasis, with primary focus on metastatic breast cancer and lung cancer
Asa Abeliovich The molecular mechanisms of neurodegeneration and the function and survival of dopamine receptors
Edmund Au Mechanisms of cortical interneuron circuit assembly and interneuron dysfunction in mental illness
Dritan Agalliu Signaling pathways and molecular mechanisms of CNS angiogenesis and blood-brain barrier formation in the developing CNS. Cell biological mechanisms of blood-brain barrier disruption in CNS pathologies.
Rando Allikmets Stargardt macular dystrophy and other retinal diseases
Ottavio Arrancio Mechanisms underlying changes of synaptic function associated with cognitive impairment
Richard Axel Defining the logic of olfactory perception
Richard Baer The pathogenesis of hereditary breast cancer
Jonathan Barasch Developmental and cell biology of kidney organogenesis
Francesca Bartolini The role of microtubule stability and its regulation in neurodegenerative disease
J. Chloe Bulinski Function of the cytoskeleton during the cell cycle and during differentiation
Robert Burke Programmed cell death in models of Parkinsonism
Julie C. Canman Molecular mechanisms of cell division
Peter D. Canoll Mechanisms of glioma growth and invasion
Lorraine N. Clark Genetics of neurodegenerative disease
Piero Dalerba Application of single-cell technologies for the analysis of tissue cell composition. Identification and clinical development of novel predictive biomarkers to guide therapeutic algorithm design in human colon and breast cancer
Riccardo Dalla-Favera Molecular genetics of cancer; molecular pathogenesis of lymphoma and leukemia
Thomas Diacovo Role of PI3Ks in immune function and leukemia
Patricia Ducy Endocrine crosstalks between the skeleton, the brain and the pancreas
Karen Duff Mouse models of Alzheimer’s Disease
Dieter Egli The generation of therapeutically relevant cells for diabetes
Ellen Ezratty Function of primary cilia in tissue stem cells
Qing R. Fan Structural biology; cell surface receptor-ligand recognition
Adolfo Ferrando Understand the molecular mechanisms that sustain the proliferation and survival of leukemic cells, and to identify novel therapeutic targets for the design of highly effective, molecularly-tailored antileukemic drugs
Jean Gautier Better understand the molecular mechanisms responsible for the maintenance of genome stability
Michael D. Gershon Structure, function and development of the enteric nervous system
James E. Goldman Glial differentiation in mammalian CNS development; progenitors in the adult CNS
Lloyd A. Greene Molecular mechanisms governing neuronal differentiation and survival
Wei Gu P53 in tumor suppression and aging
Gregg G. Gundersen The regulation and function of the microtubule cytoskeleton
Rebecca A. Haeusler Understand the development of pro-atherogenic metabolic abnormalities in the natural history of diabetes and the metabolic syndrome
Erin Heinzen Epilepsy Genetics and Genomics
Ulrich Hengst The physiological role of intra-axonal protein synthesis
Eldad A. Hod Translational research focusing on the effect of modulating iron status on innate immune mechanisms
Antonio Iavarone Molecular genetics of tumors derived from the nervous system
Un Jung Kang 1) Understanding the mechanisms of dopaminergic therapy to maximize its efficacy; 2) Understanding the mechanisms of neurodegeneration in Parkinson's disease (PD) to gain insights for potential neuroprotective therapies
Tae-Wan Kim Presenilin biology and molecular mechanism of Alzheimer's disease
Ulf Klein Germinal center B-cell differentiation: Physiology and disruption in malignancy
Stavroula Kousteni Molecular studies of skeletal physiology
Anna Lasorella Molecular biology of pediatric tumors
Roger Lefort Molecular mechanisms of neurodegeneration and synaptotoxicity in Alzheimer’s disease
Oren Levy Studying cell death pathways involved in Parkinson's disease, using cellular and animal models
Fangming Lin 1) Stem cell-based therapy to accelerate renal repair following acute kidney injury. 2) Mechanisms of renal tubular atrophy after urinary tract obstruction.
Ronald Liem The neuronal cytoskeleton and its involvement in neurodegenerative diseases
W. Ian Lipkin Immunopathogenesis and infectious diseases
Jeremy J. Mao Stem cells and multi-lineage differentiation pathways. Tissue engineering via cell delivery and growth factor approaches. Mechanobiology of skeletal structures: cells and cellular mechanics. Cell labeling and cell tracking in tissue regeneration by nanoparticles, Biomedical Engineering
Yinghui Mao Kinetochore microtubule attachment, chromosome movement, and mitotic checkpoint during mitosis
Carol A. Mason Molecular mechanisms of axon guidance and synaptogenesis
Cathy Mendelsohn Molecular pathways controlling development of urogenital tract
George Z. Mentis Developmental organization of motor neuronal circuitry
Spinal Muscular Atrophy
Umrao Monani Motor neuron disease - spinal muscular atrophy as a paradigm
Siddharta Mukherjee Understanding malignant and pre-malignant blood diseases such as Myelodysplastic Sydrome (MDS) and Acute Myelogenous Leukemia (AML)
Kenneth P. Olive Preclinical therapeutics in genetically engineered mouse models of pancreatic cancer
David M. Owens The contributions of stem cells and differentiated cells to epidermal cancer
Utpal Pajvani The role of developmental pathways, specifically Notch signaling, in obesity-induced metabolic disease, with emphasis on the pathophysiology of Type 2 Diabetes (T2D) and Non-alcoholic Fatty Liver Disease (NAFLD)
Laura Pasqualucci Elucidating the genetic basis of mature B cell malignancies, with emphasis on the two most common subtypes, diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL)
Livio Pellizzoni RNA Biology and Motor Neuron Pathology
Liza A. Pon Cytosketetal control of organelle movements and segregation during cell division
Serge Przedbrodski Toxin-induced damage to neurotransmitter systems pertinent to movement disorders
Li Qiang Posttranslational modifications (PTMs) of transcription factors in the pathophysiology of diabetes and obesity, and their associated comorbidities, including hepatic steatosis, cancer and cardiovascular diseases
Jianwen Que Molecular and cellular mechanisms controlling proliferation and differentiation of stem/progenitor cells
Kevin A. Roth Neurotransmitter and Neurotrophin Receptors and Cell Signaling
CNS Cancer Biology and Treatment
Neurodegeneration and Neurodegenerative Disorders
Ismael Santa-Maria Perez Understanding the mechanisms maintaining or altering tau proteostasis in neurons, and their relevance in aging and Alzheimer's disease 
Michael L. Shelanski Role of cytoskeleton, cell cycle machinery, and proteases in neuronal degeneration
Markus D. Siegelin Targeting apoptosis in glioblastoma.
Identification of novel drug combination therapies for glioblastoma.
Rae Silver Sleep-wake cycles and their neural bases, and immune – nervous system interactions in the brain
Janet Sparrow Cell biology of retinal disorders
Patrice Spitalnik Medical Education and Physician Scientist Training
Steven Spitalnik The biology of red blood cells
Gloria Su Molecular genetics of head and neck squamous cell carcinoma and pancreatic ductal adenocarcinoma
Ira Tabas Cellular and molecular processes related to arterial wall biology and atherogenesis
Andrew F. Teich Synaptic dysfunction in neurodegenerative disease, with an emphasis on Alzheimer's disease
Carol Troy The study of the molecular mechanisms of neuronal death with an emphasis on the regulation of caspase activity
Stephen Tsang Engineering Genome and Metabolome in Patient-specific Stem Cells
Benjamin Tycko Molecular biological studies on genomic imprinting; molecular genetics of pediatric tumors
Richard Vallee Microtubule motor proteins in axonal transport, brain developmental disease, and synaptic function
Clarissa Waites Roles of protein ubiquitination in synaptic function and neurodegeneration
Harris Wang Understanding the key principles that drive the formation, maintenance, and evolution of genomes within and across microbial populations
Hynek Wichterle The use of stem cells to study the development and function of the nervous system
Robert Winchester Autoimmunity and autoimmune disease
Howard J. Worman The studies of the inner nuclear membrane and its proteins
Ai Yamamoto Protein trafficking in Huntington’s disease and other neurological disorders
Darrell Yamashiro The role of angiogenesis in promoting the growth and metastasis of pediatric solid tumors
Shan Zha The molecular mechanisms of DNA damage response and their roles in lymphocyte gene-rearrangement
Xin Zhang Investigate the mechanism of cell signaling during eye development
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