Laboratory of Transfusion Biology


Overview

The Laboratory of Transfusion Biology at Columbia University Medical Center is a collaboration of faculty members, scientists, and trainees who are devoted to research about blood component preparation, blood storage, blood transfusion, and adverse effects caused by blood transfusion. The faculty members have subspecialty expertise in Clinical Pathology, Transfusion Medicine, Hematology, Oncology, Pediatrics, and Comparative Medicine. Their research involves studies with cell culture models, murine and canine animal models, human volunteers, and human patient populations. The Laboratory offers educational and training opportunities, hosting fellows and graduate students from around the world.

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Located in the Department of Pathology & Cell Biology in the College of Physicians & Surgeons at Columbia University, the Laboratory’s current research studies are funded by the National Institutes of Health, the Robert Wood Johnson Foundation, the National Blood Foundation, and the American Kennel Club.

Current Projects & Studies

Human Trials:

  • Effects of Transfusion of Older Red Blood Cells on Patients with Hemoglobinopathies
  • Effect of G6PD Deficiency on Red Blood Cell Storage
  • G6PD Epidemiology of Hemoglobin Variance
  • Validation of Screening Algorithm for G6PD Deficiency in the Dominican Republic Study
  • Reducing C-Section Rate in Dominican Republic HIV Patients Study
  • PICU Transfusion Study
  • Duration of Red Blood Cell Storage Prior to Transfusion and Non-Transferrin-Bound Iron                  
  • Animal Studies:

  • Storage properties of red cells from mice with genetic defects in handling oxidative stress
  • Randomized control trial in dogs with IMHA & IMT
  • Effective transfusion biofilm-related disorders
  • Effect of transfusion of host defense
  • Effect of transfusion inflammation
  • Effect of extended release pain medication of animal models of sepsis
  • In-Vitro Studies:

  • Metabolomics of RBC Storage induced damage
  • Effect of Erythrophagacytosis on bacterial clearance
  • Role of NTBI in biofilm formation
  • Red cell duration study
  • Completed Studies

  • Transfusion of human volunteers with older, stored red blood cells produces extravascular
    hemolysis and circulating non-tranferring-bound iron.
  • Contact Us

    • New York-Presbyterian Hospital/
      Columbia University Medical Center

      Laboratory of Transfusion Biology
      Columbia University College of Physicians and Surgeons
    • 630 West 168th Street
      P&S Building, Room 14-434
      New York, NY 10032
    • Lab Phone: (212) 342-5648
      Office Phone: (212) 342-5642
     
    Contact the Pathology Webmaster at PathWebMaster@columbia.edu