Immunogenetics and Cellular Immunology Laboratory

Columbia University Medical Center's Immunogenetics and Cellular Immunology (ICI) Laboratory has been a pioneer in the HLA field, with a 50-year history of excellence in clinical testing. We are certified and accredited by the American Society for Histocompatibility and Immunogenetics, the College of American Pathologists, the Centers for Medicare & Medicaid Services, and the New York State Department of Health (NYSDOH). The laboratory offers comprehensive quality testing and consultation in three distinct NYSDOH areas of accreditation: histocompatibility, cellular immunology, and transplant monitoring.

We provide a full range of pre- and post-transplant immunological tests for recipients and donors of solid organs or hematopoietic stem cells, such as:

• HLA genotyping by low- and high-resolution molecular techniques for transplantation and/or disease association studies
• Screening for anti-HLA or donor specific antibodies using complement-mediated cytotoxicity (CDC), Flow Cytometry (FC), and solid phase assays (SPA)
• Crossmatching of recipients with potential donors by CDC and FC
• Post-transplant immune monitoring by CDC, SPA, and lymphocyte growth assay

Post transplant engraftment monitoring examines donor/recipient chimerism following stem-cell transplantation using capillary electrophoretic PCR techniques, including:

• Whole-blood or bone-marrow donor engraftment
• Lineage-specific engraftment (CD3+ T, CD19+ B, CD16&56+ NK, CD15+ myeloid, CD34+ stem cell, and CD71+ erythroid precursors can be monitored independently)

Cellular immunology services include phenotypic and functional examination of hematopoietic cells obtained from peripheral blood, tissue aspirates, lymphoid, or nonlymphoid tissues:

• Leukemia/lymphoma diagnostic services
• Lymphoid immunophenotyping
• CD34 stem-cell enumeration
• Flow cytometry donor/recipient crossmatching
• Leukocyte function

ICI is an integral part of the teaching and training of residents and fellows in the Department of Pathology and Cell Biology. It also hosts several active research interests relating to transplantation outcomes, generation of immunological tolerance, and new biomarker discovery and characterization.

Contact Us

Immunogenetics and Cellular Immunology Laboratory
Columbia University Medical Center/NewYork-Presbyterian Hospital

630 W. 168th Street
VC Building, Room 15-204
New York, NY 10032

Phone Number: (212) 305-6941
Fax Number: (212) 305-3429

Lab Hours

Monday through Friday

 9:00 a.m.–5:00 p.m.